Considered among the highest-touted college football prospects, he won the 2019 National Championship Game as a freshman with the Clemson Tigers and set the school's record for quarterback wins.

Head coach Dabo Swinney named Lawrence the new starter after four games, after which Bryant announced his intention to transfer schools.

[13] Lawrence led Clemson to an undefeated regular season, a 42–10 victory over Pittsburgh in the ACC Championship Game, and a bid to play in the College Football Playoff.

[14] They advanced to the 2019 College Football Playoff National Championship game, where they defeated Alabama, 44–16, handing the Crimson Tide their worst loss of the Nick Saban era.

[15] Lawrence was named Offensive MVP of the game and became the first true freshman quarterback to start for a national champion since Jamelle Holieway in 1985 for Oklahoma.

[20][21] Lawrence helped lead Clemson to an undefeated regular season and an ACC Championship Game victory over Virginia, which gave them the No.

[28] After Lawrence returned to the team, he helped guide the Tigers back to the ACC Championship Game by finishing in second in the division-less format adopted for the 2020 season.

They defeated Notre Dame in the rematch in the conference title game with Lawrence starting at quarterback, and were selected to a spot in the College Football Playoff.

[31] He was named ACC Player of the Year, and finished in second in voting for the Heisman Trophy behind Alabama wide receiver DeVonta Smith.

[37][38] He drew comparisons to Pro Football Hall of Fame quarterbacks John Elway and Peyton Manning and 2012 first overall pick Andrew Luck,[39][40] with the slogan "Tank for Trevor" gaining popularity among fans of struggling teams.

[43] After undergoing surgery to repair a torn labrum in his left shoulder, Lawrence was officially selected first overall by the Jacksonville Jaguars, who finished with a league-worst 1–15 record the previous season.

[51] Lawrence had a stronger performance when he faced the Cincinnati Bengals in the Week 4 Thursday Night Football matchup, completing 17 of 24 passes for 204 yards and scored his first rushing touchdown, also making it his first NFL game without an interception.

[53] Following a 31–7 loss to the Seattle Seahawks, Lawrence took part in the season's biggest upset when he helped the 15.5-point underdog Jaguars defeat the Buffalo Bills 9–6.

Nevertheless, Lawrence concluded the season with his strongest performance in Week 18, completing 23 of 32 passes for 223 yards and two touchdowns to secure a 26–11 upset over the Indianapolis Colts.

[57][58] After losing to the Washington Commanders in the season opener, Lawrence won his next two games against the Colts and Los Angeles Chargers, throwing for a combined 497 yards and five touchdowns.

[64][65] The losing streak ended with a Week 9 victory over the Las Vegas Raiders, which saw Lawrence help Jacksonville overcome a 20–10 halftime deficit to win 27–20.

[70] In the season finale against the Titans to determine the AFC South, he completed 20 of 32 passes for 212 yards and one touchdown to win 20–16 and clinch the Jaguars' first division title since 2017.

[75] The next week against the eventual Super Bowl LVII champion Kansas City Chiefs in the Divisional Round, Lawrence completed 24 of 39 passes for 217 yards, a touchdown, and an interception in the 27–20 loss, marking his first defeat on a Saturday.

[76] Lawrence finished the 2022 season with 4,113 passing yards, 25 touchdowns, eight interceptions, and a 66.3 completion percentage, all noted improvements from his rookie campaign.

[85][87] In Week 7 against the New Orleans Saints, despite still being hampered by his sprained left knee, Lawrence completed 20 of 29 passes for 204 yards and one touchdown to secure a 31–24 victory.

[102] After the Jaguars dropped to 0–4 and Lawrence suffered his ninth consecutive loss as a starter, he threw for a career-high 371 yards and two touchdowns in Week 5 against the Colts, leading the team to a 37–34 victory on his 25th birthday.

[103] On November 3, in a Week 9 loss against the Philadelphia Eagles, Lawrence sustained a left shoulder injury that later identified as significant AC joint sprain; he was declared inactive for the Jaguars' following two games.