The town was separated from Baliuag by a tragic incident when around 1860, during a rainy Sunday, a group of natives from Bustos with babies in their arms were on their way to St. Augustine Parish Church of Baliuag for baptismal when they drowned after the planceta or raft they were riding accidentally capsized while crossing the wild river of Angat due to the strong water current.

This fateful event led the people of Bustos to request and build their own parish church to avoid the crossings in the wild river for community safety.

The locals chose Holy Child Jesus (Santo Niño) as their patron saint in honor of those infants that died in the river.

The Philippine Postal Corporation made a special commemorative stamp for the centennial anniversary celebration of the town.

[9] Bustos is located at the center of five adjoining towns of Bulacan: San Rafael on the north; Pandi and Plaridel on the south; Baliuag on the west; and Angat on the east.

The first church in Bustos has been dedicated to Santo Niño, the Holy Child Jesus, and there is a feast that is held in memory every third Sunday of January, where the townspeople celebrate it with music and dance while holding images of Santo Niño decorated with flowers and lights with parade of floats with images of the saint (locally known as Tugyaw).

Minasa is one of the famous treats from the province of Bulacan traded in the local and global market of Filipino pasalubong products.

During the Spanish colonial era, Bustos' minasa cookies were made from sago or arrowroot starch instead of cassava.

Also, minasas were exclusively produced and eaten by the elite Bulakeños who were the only ones who could afford the ingredients and the equipment for the production of the flour.

Minasa Festival is the official festival of Bustos observed every January where street dances, dance showdowns, cooking contests, singing contests, running events, beauty pageants, live band concerts and other variety shows are commonly done.

North Luzon Expressway has a by-pass road that passes through the municipality of Bustos that shortens the transportation of goods and passengers from some areas in Bulacan going to Metro Manila and Nueva Ecija.

The Bustos by-pass road passes through Gen. Alejo Santos Highway at Barangay Bonga Menor, Bustos, Bulacan and travels to NLEx Balagtas Exit Toll Plaza leading to Balintawak Cloverleaf, Quezon City, on one side and San Rafael, Bulacan, leading to Cabanatuan, Nueva Ecija, on the other.