[1] She has also appeared in supporting roles in numerous films, such as The Smokers (2000), Home Room (2002), White Chicks (2004), Made of Honor (2008), He's Just Not That Into You (2009), The Gift (2015), and I Feel Pretty (2018).

[8] Phillips attended Loyola Marymount University at the same time as Colin Hanks and Freaks and Geeks costar Linda Cardellini.

[3][9][10][11] While still in high school, Philipps worked at toy trade fairs as a real-life Barbie, her sister Cool Teen Skipper.

[5] Among the many people who saw her at toy conventions was actress Sharon Stone, who was impressed with her performance and told Philipps that she would be a star.

In 2006, she had a major recurring role as Hope Bobeck on ER, alongside her Freaks and Geeks co-star Linda Cardellini.

[18] On a 2010 appearance on Chelsea Lately, Philipps said that she auditioned for the hit television show Glee just one week after giving birth, following a pregnancy during which she gained 80 pounds.

[20] In 2017, she signed on as co-lead opposite Casey Wilson in Tina Fey's comedy pilot The Sackett Sisters for NBC, but it was not picked up.

[25] In October 2020 it was announced that she had joined the main cast of Peacock's Girls5eva, a musical comedy about a female pop group that reunites 20 years after it flamed out.

She said she was "bummed" by the amount of attention drawn to just this incident in the book, saying the story was not new, and that she meant it "to illustrate a larger point about the way women are treated in this business and in life.

[36] After the Alabama Legislature's May 14, 2019, passage of House Bill 314 (also known as the "Human Life Protection Act"), Philipps advocated that women speak out if they had had abortions.

[39] On June 4, 2019, Philipps gave a testimonial before the House Judiciary Committee defending women's right to access more abortion clinics.