Other notable television roles include playing Tonya Dyke in Benidorm (2014), Septa Unella in the fifth season of the HBO series Game of Thrones (2015–2016),[2] Jax-Ur in Krypton (2018–2019) and Sofia Marchetti in Sex Education (2019–2023).

Beginning in 2023, Waddingham began to expand into voice acting, portraying the snarky goddess Deliria in animated series Krapopolis (2023-present) and earning a Primetime Emmy Award for Outstanding Character Voice-Over Performance nomination, and Jinx in The Garfield Movie.

[4] She made her West End debut in ‘Saucy Jack and the Space Vixens’ at The Queens Theatre in 1998 and went on to star in Lautrec by Charles Aznavour in March 2000,[9] then created the role of Christine Warner in Andrew Lloyd Webber and Ben Elton’s The Beautiful Game, staying with the show for the year-long run at the Cambridge Theatre from September 2000.

[10] Further stage roles included Starbird in Space Family Robinson (Julian & Stephen Butler, 2002)[6] and Satan in Tonight's the Night: The Rod Stewart Musical at the Victoria Palace Theatre in 2003.

[4][27] From 2020 to 2023, Waddingham portrayed Rebecca Welton, the owner of AFC Richmond, on the Apple TV+ series Ted Lasso.

[32][33] She portrayed Lady Bellaston in the ITV drama series Tom Jones, based on Henry Fielding's 1749 novel, inspired by the real life of Etheldreda Townshend.

[36] In May 2023, Waddingham co-hosted the Eurovision Song Contest 2023 in Liverpool, alongside Alesha Dixon and Ukrainian singer Julia Sanina, with Graham Norton joining them for the final.

[37][38] Waddingham appeared in the 2024 action-comedy film The Fall Guy alongside Ryan Gosling and Emily Blunt, playing producer Gail.

[39] In 2000, Waddingham played the role of Christine in the Andrew Lloyd Webber and Ben Elton musical The Beautiful Game in London's West End.

In October 2000, Waddingham (billed simply as "Hannah"), released a single of the song "Our Kind of Love" from the production.

Records in May 2002, coinciding with the stage production (also featuring Waddingham as Starbird) which ran for three weeks at London's Pleasance Theatre.