Charles Edward "Buzz" Wetzel (August 25, 1894 – March 7, 1941) was a pitcher in Major League Baseball who played briefly for the Philadelphia Athletics during the 1927 season.

Wetzel was 32 years old when he entered the majors on July 27, 1927, and did not have a decision or strikeouts.

Wetzel posted a 7.71 earned run average in two games, including one start, giving up four earned runs on eight hits and five walks in 4+2⁄3 innings of work.

Following his majors career, Wetzel pitched and managed in the minor leagues.

This biographical article relating to an American baseball pitcher born in the 1890s is a stub.