[7] Buxton committed to a college baseball scholarship with the University of Georgia, intending to attempt to walk on to the football team.

[14] After he batted .340 with eight home runs and 32 stolen bases to start the season, the Twins promoted Buxton to the Fort Myers Miracle of the Class A-Advanced Florida State League in June.

[25] He injured his left wrist, spraining his pisotriquetral joint, while diving for a ball and opened the 2014 season on the disabled list.

[28] Buxton batted .240 in 30 games before receiving a promotion to the New Britain Rock Cats of the Class AA Eastern League on August 11.

[35][36][37] Buxton opened the 2015 season with the Twins' new Class AA affiliate, the Chattanooga Lookouts of the Southern League.

[42] The Twins activated Buxton from the disabled list on August 10 and optioned him to the Rochester Red Wings of the Class AAA International League, due to the strong play of Aaron Hicks.

[44] According to Statcast, Buxton led MLB in average sprint speed at 30.8 feet per second, after tying with Jarrod Dyson for the lead in the previous season.

[55] Buxton's 2018 season got off to a sloppy start, as he spent some stints on the disabled list due to a toe injury and migraines.

[58] On April 22, 2019, Buxton's streak of 33 stolen bases was ended after he was caught stealing by Robinson Chirinos of the Houston Astros.

[59] In the abbreviated 2020 Major League Baseball season, Buxton played 39 of Minnesota's 60 games, primarily missing time due to a shoulder injury sustained in late-August.

Buxton was named the American League Player of the Month for April 2021, when he hit .426 with 8 home runs and 14 RBIs.

[62] When Carlos Correa joined the Twins for the 2022 season, he and Buxton became the third pair of players picked first and second in the same draft to then play for one club.

[63] On June 9, 2022, the trio of Luis Arráez, Buxton, and Correa each hit consecutive home runs off Gerrit Cole to open the bottom of the first inning versus the New York Yankees.

[64] In June 2022, Buxton hit his 44th home run since he had last grounded into a double play, which occurred on September 7, 2020, surpassing a record of 43 held by Matt Carpenter.

[65] On July 5, 2022, Buxton started the first 8–5 triple play in major league history when he caught an A. J. Pollock fly ball at the wall in the bottom of the seventh inning versus the Chicago White Sox .

Buxton threw to third baseman Gio Urshela, who tagged a retreating Yoán Moncada out at second base and stepped on the bag to retire Adam Engel.

[66] During 2023 spring training, Buxton was moved to being Twins primary DH in efforts to keep him in lineup for full season.