Côme Isaïe Rinfret (September 6, 1847 – November 8, 1911) was a Canadian physician and politician.

Born in Cap-Santé, Portneuf County, Canada East, the son of F. J. Rinfret, Rinfret was educated at the Seminary of Quebec and studied medicine at Victoria University, Montreal from which he graduated with the degree of M.D.

He was first elected to the House of Commons of Canada for the electoral district of Lotbinière in the 1878 federal election.

He resigned in 1899 when he was appointed inspector of Inland Revenue.

This article about a Quebec Member of Parliament from the Liberal Party of Canada is a stub.