It begins at the Décarie Expressway in Snowdon, part of the borough of Côte-des-Neiges–Notre-Dame-de-Grâce, and runs east and southeast along the periphery of Mount Royal to Park Avenue in the Plateau, terminating near Mount Royal Avenue.

Outremont's borough (formerly city) hall is located on this street, as is Beaubien Park.

Further west in Côte-des-Neiges, it houses the Jewish General Hospital, the CHU Sainte-Justine hospital, Collège Jean-de-Brébeuf, the Montreal Holocaust Museum, and the Segal Centre for Performing Arts.

The Montreal Metro provides ample coverage around the western portion of the street.

Côte-Sainte-Catherine station on the Orange Line is located at its corner with Victoria Avenue, while the Blue Line runs a few blocks to the south, across the campus of the Université de Montréal.