Route 112 is a busy east–west highway on the south shore of the Saint Lawrence River in Quebec, Canada.

Its eastern terminus is in Frampton at the junction of Route 275, and the western terminus is in Downtown Montreal (at the corner of Peel Street and Sherbrooke Street), after crossing the Victoria Bridge.

The stretch between Vallée-Jonction and Sherbrooke is a very busy highway as it is the main link between the southern regions of Quebec, in particular the Beauce region and the Eastern Townships.

Between Sherbrooke and Marieville there is less traffic, since Autoroute 10 is in close proximity to the highway.

It has been the road connecting most of the Eastern Townships to Montreal for decades as Route 1.