Luberon (French pronunciation: [lyb(ə)ʁɔ̃] or [lybeʁɔ̃]; known as Côtes du Luberon until 2009) is a French wine-growing AOC in the southeastern extreme of the Rhône wine region of France, where the wines are produced in 36 communes of the Vaucluse département.

The neighbouring appellation of Ventoux AOC stretches along its northern border and is separated by the Calavon river.

The vineyards are in the communes of Ansouis, Apt, La Bastide-des-Jourdans, La Bastidonne, Beaumont-de-Pertuis, Bonnieux, Cabrières-d'Aigues, Cadenet, Castellet, Cheval-Blanc, Cucuron, Goult, Grambois, Lacoste, Lauris, Lourmarin, Maubec, Ménerbes, Mérindol, Mirabeau, La Motte-d'Aigues, Puget, Puyvert, Robion, Saignon, Saint-Martin-de-Castillon, Saint-Martin-de-la-Brasque, Sannes, Taillades, La Tour-d'Aigues, Vaugines, Villelaure, Vitrolles-en-Luberon.

White wines from Ugni blanc (maximum 50%), Roussanne & Marsanne (combined maximum of 20%), Clairette blanche, Grenache blanc, Vermentino, and Bourboulenc.

The wines received AOC status in 1988, under the name Côtes du Luberon.