Saint-Martin-de-Castillon (French pronunciation: [sɛ̃ maʁtɛ̃ də kastijɔ̃]; Occitan: Sant Martin de Castilhon) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.

The river Calavon flows westward through the middle of the commune and forms part of its western border.

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