He played college football for the Notre Dame Fighting Irish.

Prosise attended Woodberry Forest School in Madison County, Virginia.

[1] He committed to the University of Notre Dame to play college football over offers from Penn State, North Carolina, Vanderbilt, Virginia Tech, among others.

[5] After a season-ending injury to Tarean Folston versus Texas, Prosise became the starter.

[15] Following Notre Dame's loss against Ohio State in the Fiesta Bowl, Prosise announced he would forego his remaining eligibility and enter the 2016 NFL draft.

[22] Prosise also started the Week 11 game against the Philadelphia Eagles and scored his first career touchdown, a 72-yard run, but suffered a fractured scapula that ended his rookie season.

[25] In 2018, Prosise played in five games before being placed on injured reserve with abdomen, groin, and hip-flexor injuries.

[39] On January 6, 2021, Prosise signed with the practice squad of the Tampa Bay Buccaneers.