A native of Houston, Ifedi attended Westside High School, where he was a three-sport athlete in football, basketball, and track.

The Westside Wolves went 10–4 on the season, losing the UIL 5A Division II Regional Final to Dekaney, which were led by running back Trey Williams.

[3][4] After redshirting in his first year at Texas A&M, Ifedi started at right guard all 13 season games on the offensive line in 2013.

[12] He became the fourth consecutive Texas A&M Aggies offensive lineman selected in the first round of an NFL Draft, after Luke Joeckel (2013), Jake Matthews (2014), and Cedric Ogbuehi (2015).

[14][15] Ifedi made his first career start and NFL debut on October 2, 2016, against the New York Jets in Week 4 after missing September due to an ankle injury.

[20] On May 3, 2019, the Seahawks declined the fifth-year option on Ifedi's contract, making him a free agent in 2020.

[22] On April 1, 2020, Ifedi signed with the Chicago Bears on a one-year deal.

His older brother, Martin Ifedi, played defensive end for the Memphis Tigers.

His eldest brother, Benedict Ifedi, is a Primary Care-Sports Medicine Physician in Katy, Texas.

[48] He interned with Manhattan-Vaughn Construction in 2015, the joint venture which renovated Kyle Field.