Mudaliar founded the Madras United League in 1912 and was one of the founders of the South Indian Liberal Federation.

He worked as a lecturer in Pithapuram Maharaja College and as an interpreter in the Gordon Woodrof Company.

The league was largely composed of government employees and concentrated on improving the literacy of non-Brahmins by conducting adult education classes.

Mudaliar had discovered that caste restrictions prevented non-Brahmins from finding hostel lodging in Madras.

[citation needed] Mudaliar, along with Chetty, was instrumental in negotiating an end to the Buckingham and Carnatic Mills strike of 1921, organized by V.

[citation needed] Natesan was expected to contest in the 1937 elections to the legislative assembly of Madras but he died suddenly in February 1937 at the age of 62.