Ramaswami Iyer; the future Raja Sir T. Madhava Rao, to whom he was tutor,[8] who would successively govern Travancore, Baroda, and Indore as Diwan; Madhava Rao's cousin R. Raghunatha Rao, who would also govern as Diwan of Indore; another future Diwan of Travancore, V. Ramiengar; T. Muthuswami Iyer, who would become the first Indian justice of the High Court; Ramiengar's Vembaukum clan-cousin V. Sadagopacharlu, the first Indian advocate before the Court and member of the Madras Legislative Council; and P. Padasiva Pillai, who would become Supreme Justice of the High Court in Travancore, among others.

But the hostile attitude of the government, as well as his father's failing health, forced Runganada Sastri to return to Chittoor where he got a position as a clerk in the Subordinate Judge's Court at a salary of Rs.

During this time, Sastri displayed his rare aptitude for languages, mastering Telugu, Marathi, Hindustani, Persian and Kannada, in each of which he demonstrated himself to be unsurpassed in the reckoning when formally examined for the role of Chief Interpreter into the Supreme Court at Madras.

[9] In German, Sir P. S. Sivaswami Iyer further recorded the Hamburger Gustav Solomon Oppert, who arrived in 1872 from Oxford to take up the Professorship of Sanskrit and Comparative Philology, affirming his native-like facility with.

[12] In April 1859, there was a vacancy in the Small Claims Court Bench and Runganada Sastri was appointed to the post by the then Governor of Madras Sir Charles Trevelyan after encountering heavy opposition and racial prejudice.

Runganada Sastri served as a judge of the Small Claims Court from April 1859 until his retirement with a pension on 16 February 1880, whereupon he was appointed to the Madras Legislative Council.

[9] Among his great-grandsons, Venkataraman Sastri became Shankaracharya and pontiff of the Dwaraka Math for a brief stint, as Swami Bharati Krishna Tirtha Maharaj, before succeeding as supreme pontiff of the Govardhan Math and highest authority in Smarta Hinduism, in which capacity he would become the first Shankaracharya to visit the West, being additionally known for the formulation of Vedic mathematics; C. R. Pattabhiraman Iyer was an elected MP and served as Minister of Law and Justice under Indira Gandhi; while Dewan Bahadur V.N.

Other descendants include Aryama Sundaram, variously justice of the Supreme Court of India, Chief Justice of the Punjab and Haryana High Court, and justice of the Supreme Court of Singapore; C. V. Ranganathan, Joint Foreign Secretary and successive Indian Ambassador to the Soviet Union during Perestroika, Ambassador to China post Tiananmen Square, and France; archaeologist Sharada Srinivasan, as well as in-law M. R. Srinivasan, celebrated Chairman of the Atomic Energy Commission of India and Secretary of the Department of Atomic Energy, who was awarded the Padma Bhushan for his work with Homi J. Bhabha developing Apsara (disambiguation), the first Indian nuclear reactor, and then the Pressurized heavy-water reactor.