C1orf68

Chromosome 1 open reading frame 68, or C1orf68, is a human gene which encodes for skin-specific protein 32.

[2][3] C1orf68 is mapped on the plus strand of chromosome 1 at 1q21.3, that spans 949 base pairs in the human genome.

[4] It also contains a cysteine rich region, which is shown to be conserved across most mammal orthologs, excluding Monotremes.

[15] It has also been noted that C1orf68 is moderately expressed in stratum corneum and granular layer of skin.

The stem loop containing PUM2 RNA protein binding site, which was shown in all of the predicted structures created by mFold.

The rate of evolution of C1orf68 was observed to be fast when comparing to cytochrome c and fibrinogen alpha.

[21] Also showed enhanced protein and mRNA levels in chronic skin lesions, such as in psoriasis.

[21] Zinc finger E-box-binding homeobox 1 has been shown to regulate corneal epithelial terminal phenotype.

[23] It has also been shown that GATA3 induces differentiation of primary keratinocytes, and suggested that it may regulate human interfollicular epidermal renewal.

Human C1orf68 conceptual translation of mRNA and protein sequence
Diagram of human C1orf68 protein domains, which includes PRK10263 (DNA translocase Ftsk) and cysteine-rich region
LOGO of repeat sequences in human C1orf68 conserved across select orthologs, Rhinopithecus roxellana (Golden snub-nosed monkey), Cavia porcellus (Guinea Pig), and Myotis brandtii (Brandt's bat)
Human C1orf68 (exon 1) with Promoter GXP_1818199 diagram. Start and stop codons represented as green and red arrows respectively.
Predicted C1orf68 3’-UTR mRNA secondary structure with a Gibbs free energy of -41.19, created by mFold. [ 17 ]
Rate of evolution comparison between C1orf68, Cytochrome C, and Fibrinogen Alpha. C1orf68 appears to evolve at a similar rate to Fibrinogen alpha, which serves as a standard for rapidly evolving genes. Showing how the corrected % divergence (m) changes over time (Date of Divergence (MYA) Median Time). [ 20 ]