1BBR, 1DM4, 1FPH, 1FZA, 1FZB, 1FZC, 1FZD, 1FZE, 1FZF, 1FZG, 1LT9, 1LTJ, 1N86, 1N8E, 1RE3, 1RE4, 1RF0, 1RF1, 1YCP, 2A45, 2FFD, 2H43, 2HLO, 2HOD, 2HPC, 2OYH, 2OYI, 2Q9I, 2XNX, 2XNY, 2Z4E, 3AT0, 3BVH, 3E1I, 3GHG, 3H32, 3HUS, 4F27, 5CFA224314161ENSG00000171560ENSMUSG00000028001P02671E9PV24NM_000508NM_021871NM_001111048NM_010196NP_000499NP_068657NP_001104518NP_034326Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene.

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains.

Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots.

Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia, and renal amyloidosis.

[5] Fibrinogen alpha chain has been shown to interact with tissue plasminogen activator.