4BFG, 4BFI13145057781ENSG00000163606ENSMUSG00000022667Q8TD46Q9ES57NM_138806NM_138939NM_138940NM_170780NM_021325NP_620161NP_620385NP_620386NP_740750NP_067300Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.

[14] CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha),[15] interferons, and inducible nitric oxide synthase (iNOS).

Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains.

Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner.

[7] This article incorporates text from the United States National Library of Medicine, which is in the public domain.