[4] In December 1956, Universidad Católica was placed at the bottom of the league table and relegated to Segunda División for the first time in its history.

[11] The team had previously eliminated clubs Atlético Nacional (2–0, 1–2 in round of 16), Barcelona (3–1, 1–1 in  quarterfinals) and América de Cali (1-0, 2–2 in semifinals).

[13] With Manuel Pellegrini as manager, on 1 November 1994, after beating Saprissa 5–1 at San Carlos de Apoquindo with goals by Andrés Romero, Alberto Acosta, Juvenal Olmos, Miguel Ardiman and Rodrigo Barrera, Universidad Católica became the second Chilean team to win a Copa Interamericana,[14] they also achieved the 1995 Copa Chile title.

[15] In 1997 the club celebrated its 60th anniversary with a friendly tournament where they beat Ajax Amsterdam 3–2 in the Copa 60º Aniversario de Universidad Católica.

[17] In 2005 the club has been reemerged in international competition, advancing to the 2005 Copa Sudamericana semifinal before being knocked out by the powerful Boca Juniors from Argentina, who would go on to win the tournament.

[19] In 2006 the team made a good presentation in the Copa Libertadores, but was eliminated at the last minute by Tigres UANL of Mexico and failed to advance beyond the group stage.

[20] Católica again played 2008 Copa Libertadores with no luck, being eliminated in the group stage by goal difference by River Plate and América.

[24] In the last match, Universidad Católica defeated Everton 5–0 to secure the club's ten Chilean Primera Division title and end a five-year trophy drought.

[30] In Copa Sudamericana 2012, Universidad Católica advancing to the semifinal before being knocked out by the powerful São Paulo from Brazil,[31] who would go on to win the tournament.

Two goals in the last half-hour secured Universidad Católica a 2–0,[36] with Mario Salas leading the team towards its first Bicampeonato for winning two national titles in a row.

[37] With Beñat San José as manager, Universidad Católica won the title 2018 on the last matchday after beating Deportes Temuco 2–1.

[46] On 14 February 2020, with Ariel Holan Universidad Católica secured their third consecutive Primera División title,[47] they also achieved the semi-finals of Copa Chile.

[51] In 2021 Copa Libertadores, Católica finished second on the group stage,[52] and then advanced to the round of 16, before being knocked out by the Palmeiras from Brazil,[53] who would go on to win the tournament.

[56] On 20 January 2021, Universidad Católica won their four Supercopa de Chile title, after beating Ñublense's in a penalty shootout.

[71][72] The Universidad Católica has attained fame as a favorite of the higher classes, because of many factors, which range from the location of the club's stadium, San Carlos de Apoquindo (in one of the most exclusive neighborhoods of the capital) and Headquarters, although there are "UC" fans all around the country, including popular regions or towns.

Due to the neighborhood's strong influence (wealthy families), the club has been unable to be approved for projects to enlarge the stadium and thus draw larger crowds.

Only until in recent years the club was allowed by the commune of Las Condes, to host their clasicos matches against Universidad de Chile and Colo-Colo in their own stadium.

Although just a limited number of its rivals' supporters are allowed to be present at these matches due to security reasons inside the stadium and around its high-end neighborhood.

[76] Four other players have also scored over 100 goals for Universidad Católica: Alberto Fouillioux (1957-1975),[77] Néstor Isella (1963-1970),[77] Osvaldo Hurtado (1980-1988t)[77] and the previous goalscoring record-holder Raimundo Infante (1941-1956).