The club was founded by workers of the Mexican mining company called "Compañia Real del Monte y Pachuca", which had mostly British miners immigrants from Camborne and Redruth (Cornish diaspora), who were the first to introduce football to Mexico.

Nicknamed "Tuzos", it pays tribute and refers to the history and mining heritage of the club and the city of Pachuca.

The game rapidly spread in popularity and other clubs soon were established in surrounding states, including Orizaba, Puebla and Mexico City.

Between 1920 and 1921, the mining company entered into crisis due to the effects of the Mexican Revolution, which is why the most of its players moved to Mexico City.

Their first match was a 1–3 loss against Necaxa at the Estadio Azteca, where Armando Cuervo became the club's first scorer in the top professional division.

In the 1998–99 season, the team breaks its own bad streak with a draw against Atlante in the Estadio Azteca in front of 30,000 people and avoids returning to the Primera División A.

It started in the Invierno 1999 tournament, Pachuca under the coach Javier Aguirre were crowned champions of the Primera División de México for the first time in its history.

Pachuca again under Javier Aguirre, are finalists in the Verano 2001 tournament, losing to Santos Laguna at the Estadio Corona in Torreón, Coahuila.

During that season, the team lost one of its biggest figures when Pablo Hernán Gómez was killed in a car accident on January 29, 2001.

Tena leads the team to the Invierno 2001 finals where they faced Tigres UANL in the Estadio Universitario and winning their second league title.

As a result, Pachuca won the Clausura 2006, beating San Luis 1–0 on aggregate with a penalty goal scored by the striker Richard Nuñez, after having an exceptional season which saw the club top the general standings table.

[9] In the finals they were matched up with Colo-Colo, one of Chile's most historic and popular clubs; the first leg in Mexico finished in a draw 1–1.

[11] With the Clausura 2006 title, Pachuca qualified for the 2007 CONCACAF Champions' Cup, where they disposed of W Connection and D.C. United, before defeating Guadalajara (7–6 on penalties) in the final after a 2–2 draw on aggregate on April 25, 2007.

The alliance included a home-and-home annual series between the clubs, an exchange of best business practices, and the establishment of the Tuzos Soccer Academy at Dick's Sporting Goods Park, which was officially launched on October 1, 2007.

With the 2007 CONCACAF title, Pachuca claimed a spot in the 2007 FIFA Club World Cup, where they had a disappointing performance, being knocked out by their first rival in the tournament, Étoile Sportive du Sahel (CAF champions).

With this victory, they secured a spot in the 2017 FIFA Club World Cup, where they had a respectable performance and achieving third place, defeating Al Jazira 4–1.

Originally the colors used by the club were black and white, during its participation in the Liga Mexicana Amateur de Football Association from 1902 to 1920.

The first football field used by the club in the amateur league was the Campo del Ferrocarril de La Maestranza (English: Railway Field of La Maestranza), where a factory and workshops of the Compañia Real del Monte y Pachuca were located behind the city's old railway station.

After the club was refounded in 1960, they moved to the Estadio Revolución Mexicana (English: Mexican Revolution Stadium) with a capacity of just over 3,000 seats and inaugurated on December 14, 1958.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.