CGK733 was a synthetic chemical substance which was reported in 2006 to have remarkable properties in reversing cell senescence (aging).
[1] However, the entire work behind the discovery of this compound has since been found to be falsified and the authors of the original reports have retracted all their claims.
[2][3] CGK733 was claimed to be an inhibitor of ATM/ATR kinases,[4][5] which are involved in DNA damage repair.
[7] The retraction states that the screen to identify CGK733 as an anti-senescence agent was not carried out; experiments exploring the cellular effects of CGK733 were misrepresented; the identification of ATM as the target of CGK733 was fabricated; a compound which was essential for ATM target validation had not been synthesized; and the chemical structure of CGK733 was misrepresented.
[7] The principal investigator, Tae Kook Kim, and several associates were consequently suspended from their positions at the Korea Advanced Institute of Science & Technology.