Since 2013, it has partnered with Eunoia Junior College for a six-year Integrated Programme, which allows its secondary school students to skip the Singapore-Cambridge GCE Ordinary Level examinations and proceed to Eunoia for Years 5 and 6 and take the Singapore-Cambridge GCE Advanced Level examinations at the end of Year 6.

At that time the entire teaching staff consisted of only two people, the principal who taught English, and another teacher who served as a Chinese instructor.

[1] At that time, the principal, Sister Francoise Lee, felt the need to cater to Chinese Catholic girls.

The former building complex was a hotbed for prostitution activities, thus the purchase would indirectly reduce such influence on the girls living in the convent.

The already strong bilingual culture of the school thus allowed it to adapt seamlessly to the SAP scheme, bringing it out of its precarious situation and giving it a new shot at prominence.

[11] On 23 August 1986, the new campus for St. Nicholas Girls' School at Ang Mo Kio Street 13 was declared open by Education Minister Tony Tan.

[15] In 2013, CHIJ St Nicholas Girls' School finished its rebuilding and was declared open by Prime Minister Lee Hsien Loong.

In 2012, students from CHIJ St Nicholas Girls' School topped the Singapore-Cambridge GCE Ordinary Level examinations for the fourth consecutive year.

[17][18] In 2018, CHIJ St Nicholas Girls' School introduced the return of a popular canteen stall from the old convent.

Under the programme, students skip the Singapore-Cambridge GCE Ordinary Level examinations in their respective schools, and move to Eunoia Junior College for pre-university education in Years 5 and 6 and sit for the Singapore-Cambridge GCE Advanced Level examinations at the end of Year 6.