CKLF like MARVEL transmembrane domain-containing 8 (i.e. CMTM8), previously termed chemokine-like factor superfamily 8 (i.e. CKLFSF8) has at least two isoforms, the CMTM8 and CMTM8-v2 proteins.
[1] Protein isoforms are variant products that are made by the alternative splicing of a single gene.
The gene for these isoforms, CMTM8 (formerly termed CKLFSF8), is located in band 22 on the short (i.e. "p") arm of chromosome 3.
The low levels of CMTM8 protein in bladder[6] and stomach[7] cancer tissues were associated with more aggressive diseases (e.g. presence of metastases) and poorer prognoses.
However, further studies are required to support these conclusions and to determine if the levels of CMTM8 protein can be used as prognostic markers for these malignancies and/or as a targets for treating them.