112616102545ENSG00000153551ENSMUSG00000032436Q96FZ5Q9ESD6NM_138410NM_181472NM_001252479NM_133978NP_612419NP_852137NP_001239408NP_598739CKLF like MARVEL transmembrane domain-containing 7 (i.e. CMTM7), previously termed chemokine-like factor superfamily 7 (i.e. CKLFSF7), is a protein that in humans is encoded by the CMTM7 gene.

This gene, which is located in band 22 on the short (i.e. "p") arm of chromosome 3, and the protein that it encodes belong to the CKLF-like MARVEL transmembrane domain-containing family.

Through the process of alternative splicing, the CMTM7 gene encodes two isoforms, CMTM7-v1 and CMTM7-v2, with CMTM7-v1 being the main form expressed and studied.

[5][6] CMTM7 protein levels are low in the malignant tissues of various cancers such as those of esophagus, stomach, pancreas, liver, lung, cervix,[5] and breast.

[5] However, further studies are needed to support these suggestion and determine if expression of the CMTM7 can be used as a clinical marker of these cancers severity/prognosis and/or as therapeutic targets for treating them.