It is the lead agency of the Muñoz Science Community and the seat of the Regional Research and Development Center in Central Luzon.

To date, CLSU is one of the premiere institutions for agriculture in the Philippines and in Southeast Asia known for its research in aquaculture, ruminants, crops, orchard, and water management.

It has also been placed between the sixth and the twenty-first spot for the most academically-excellent university in the country for various years, surpassing most schools in Metro Manila.

The university is the lead agency of the Muñoz Science Community and the seat of the Regional Research and Development Center in the Central Luzon.

On April 1, 2024, a Memorandum of understanding was signed by CLSU President Evaristo A. Abella, the University Extension Program Office, CLSU Vice President for Research and Extension Dr. Edgar A. Orden and Guimba Mayor Jesulito E. Galapon for the establishment of the Technology Village Development Program in Guimba.

It has a more than 1,000-hectare (2,500-acre) site for ranch-type buffalo production and forestry development up the hills of Carranglan town, in northern Nueva Ecija, 40 km (25 mi) from the main campus.

[14] Made of wood, steel frame and concrete, with a galvanized iron roof, the building was later fitted with acoustics for cinema functions and bowling alleys.

Among the other prominent guests were senators, congressmen, Cabinet members, diplomats, school officials and representatives of the country's top universities and colleges.

[citation needed] Magsaysay would have returned to Reimer's Hall on April 5, 1955, as Philippine president during the golden jubilee and graduation programs, but he died in a plane crash on March 17, 1955.

Two empty chairs, draped in black, and a speaker's stand decorated with academic regalia, diploma and citations for Magsaysay were set up on the stage to remember the late president.

[14] A modern auditorium was later built beside Reimer's Hall during the time of then CLSU president Amado Campos, who changed the complexion of the campus with his more than P45-million infrastructure build-up during his term from 1972 to 1986.

Its initial emphasis was on the development of skilled and technician-type graduates to meet the human resource requirements in the opening and cultivation of rich farmlands.

"[19] From its basically agricultural orientation, CLSU turned into a comprehensive higher education institution offering various undergraduate and graduate courses.

The R & DC adopted the pipeline approach as its strategy to spur countryside group for information and technology dissemination and contribute to the realization of the university's development goals.

Today, the Research Office has received prominence and has established a solid ground in its continuous and relentless efforts towards contributing to countryside development.

As of December 2020, CLSU is among the top 14 universities in the Philippines that is listed in Asia's Higher Education Institutions (HEIs) by Quacquarelli Symonds.

CLSU specializes on agriculture, aquaculture, business administration and accountancy, veterinary medicine, biology, chemistry, and engineering.