4352, a vocational institution in Sogod, tasked to answer the problem of lack of manpower training for adults and out of school youths.

Republic Act 9261 [5] which was enacted and approved by Congress and the Senate Republic of the Philippines on March 7, 2004, established the Southern Leyte State University by integrating the Southern Leyte State College of Science and Technology in the Municipality of Sogod and Tomas Oppus Normal College in the Municipality of Tomas Oppus.

With this development, five higher education campuses were integrated to comprise the university since SLSCST has been made host to three other CHED-supervised institutions in October 1999.

[7] Eventually, RA 9261 [5] established the Southern Leyte State University - Hinunangan after its integration with SLSCST in 1999.

On November 22, 1985 BP Bilang 888 renamed the school to Ruperto K. Kangleon Memorial Agro-Fisheries Technical Institute (RKKMAFTI).

Eventually, RA 9261 [5] established the Southern Leyte State University - Bontoc after its integration with SLSCST in 1999.

[10] Eventually, RA 9261 [5] established the Southern Leyte State University - San Juan after its integration with SLSCST in 1999.

In 2018, By virtue of RA 11079,[11] the established Maasin City College was integrated to Southern Leyte State University and is now known as Southern Leyte State University - Maasin City Campus offering Bachelor of Public Administration and Bachelor of Science in Social Work.