2592058202ENSG00000188986ENSMUSG00000013465Q8WX92Q8C4Y3NM_015456NM_021393NM_001310157NP_056271NP_001297086NP_067368Cofactor of BRCA1, also known as COBRA1, is a human gene[5] that encodes NELF-B.

NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (WHSC2; MIM 606026), either NELF-C or NELF-D (TH1L; MIM 605297), and NELF-E (RDBP; MIM 154040).

NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660).

[6] COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of BRCA1 as bait.

[7] Cofactor of BRCA1 has been shown to interact with: