The organization aims at sustainable socio-economic uplift of the developing countries through scientific and technological means while adopting North–South and South–South cooperation.

The network is also assisted by the Technical Advisory Committee (comprising senior scientists and technologists from the North and the South).

Currently, Prof. Dr. Ashraf Shalan, Former President, National Research Centre (NRC), Egypt is the Chairperson of COMSATS' Coordinating Council.

In this context, the organization focuses on: Keeping in view the common goals of building and promoting indigenous capacities in science and technology for science-led development, COMSATS has signed a number of Memoranda of Understanding (MoU) with various Ministries, International Organizations and Academic Institutions, to effectively conduct developmental initiatives.

Also, the organization has close working relations with various development and donor agencies, such as UNESCO, ISESCO, TWAS/TWNSO, COMSTECH, ICGEB, South Centre, IOFS, etc.