COS are fibroblast-like cell lines derived from monkey kidney tissue.
[2] The CV-1 cell line in turn was derived from the kidney of the African green monkey.
[3] The acronym "COS" is derived from the cells being CV-1 (simian) in Origin, and carrying the SV40 genetic material.
The COS cell lines are often used by biologists when studying the monkey virus SV40.
These COS cells are genetically modified to produce the T antigen from their own genome.