[4] December 13: South Carolina announced that they will begin to receive Pfizer COVID-19 vaccine soon, and it will be prioritized for healthcare workers and nursing home staffs.

[56] However, DHEC began to report cases and deaths in nursing homes weekly on April 21, 2020, in response to a suit and publicity about the lack of disclosure.

Initial models suggested that South Carolina would reach its peak in COVID-19 cases in April, with 680 deaths estimated by August 4.

[73][74] As of July 15, a model from independent researchers at Pandemic Central provides daily new case projections for counties in South Carolina and elsewhere.

[78] In late April, McMaster established the accelerateSC task force to assess and recommend economic revitalization plans for South Carolina during the pandemic.

[82] The report contains 42 recommendations including using federal aid for the state unemployment trust fund, for expanding internet broadband access, to add five days of school for K-8 education, and for health care costs.

[92] However, Spearman stated that "School leaders, in consultation with public health experts, are best positioned to determine how in-person operations should be carried out to fit the needs of their local communities",[93] and teachers also expressed concern about re-opening in person.

[103] Clemson University announced that they will reopen for in-person learning this fall with all students and staff required to be tested for COVID-19 within five days prior to arriving on campus.

McMaster announced that the eight Historically Black Colleges and Universities in South Carolina would be allocated $2.4 million to enhance online learning from the Governor's Emergency Education Relief (GEER) fund.

In early September a 28 year old elementary school teacher died in Columbia, South Carolina from COVID-19 related complications.

[109] This affected South Carolina especially, as the Bon Secours Wellness Arena in Greenville was set to host first and second-round games in the women's tournament.