[13] Since the start of the Russian invasion of Ukraine, the Ukrainian Ministry of Healthcare has made no further press releases related to COVID-19, and the latest counts were for 23 February 2022.

[16] On 12 January, the World Health Organization (WHO) confirmed that a novel coronavirus was the cause of a respiratory illness in a cluster of people in Wuhan, Hubei, China, who had initially come to the attention of the WHO on 31 December 2019.

[21][19] On 27 January 2020, SkyUp, a Ukrainian low-cost charter airline, announced that it had suspended flights to Sanya, in Hainan, China until March.

The woman, from Radomyshl, in Zhytomyr Oblast, died on 13 March, becoming the first fatal case in the country.

[32] On 18 March, member of the Ukrainian parliament Serhii Shakhov stated that he was SARS-CoV-2 positive after denying it earlier in the day.

Kyiv Post counted Shakhov as being among the total of 14 people in Ukraine with laboratory confirmations of being SARS-CoV-2 positive.

[38] On 20 March, the first case of recovery from COVID-19 was reported for a man in Chernivtsi who was the first infected person in the country.

[39] On the same day, 15 new positive COVID-19 tests were confirmed across Ukraine: 10 in Chernivtsi Oblast, and one in each of Lviv, Ivano-Frankivsk, Kharkiv, Ternopil, and Kyiv, raising the national total to 41 cases.

[42][43][44] There were either six[43] or seven new cases confirmed in Kyiv bringing the total to ten (of these eight had caught the disease abroad).

[51] On 25 March, the Government introduced a 30-day emergency regime across Ukraine that was scheduled planned to end on 24 April.

[60] On 21 April, it was reported that the Ministry planned to request an extension of the quarantine until 12 May, albeit with some exceptions, such as opening libraries and museums.

[63] These included the re-opening of parks, squares, recreation areas, beauty salons, hairdressers and barber shops, cafes and restaurants with outdoor tables.

The second stage of easing the quarantine is currently scheduled for 22 May,[64] which envisages the reopening of nurseries, public transport, and hotels, and allowing sports competitions to be held.

[66] Domestic flights resumed on 5 June, along with the reopening of restaurants, cafes and religious establishments.

[67] International flights resumed on 15 June, but as of this date, Ukrainians could only travel to Albania, Belarus, the UK, US, and Turkey.

On 8 January, Ukraine introduced a new lockdown in an effort to curb high daily infection numbers.

"[75] An antibody study done by Synevo laboratories showed that in January 2021 already 44% to 60% of all Ukrainians depending on region were infected compared to 33% in October 2020 and 9% in July 2020.

[6][7] On 25 October Ukrainian health authorities reported a record daily high of 734 coronavirus-related deaths and 19,120 new infections.

[78] On 11 December 238 coronavirus-related deaths were reported, 5,275 cases of infections were detected and 11.6 thousand people recovered from COVID-19.

[78] As the Russian invasion of Ukraine broke out, there were concerns that COVID-19 may become a bigger problem moving forward, alongside a polio epidemic.

[16] Vactination against COVID-19 in Ukraine started on 24 February 2021,[77][81] but the tempo of vaccinating has been extremely slow compared to other European countries.

[11] On 14 October 2021 Prime Minister Denys Shmyhal stated that all of the country's adult population should be vaccinated against COVID-19 by the end of the year.

[85] In August 2021 56% of Ukrainians polled by the Ilko Kucheriv Democratic Initiatives Foundation did not plan to be vaccinated.

[86] The most chosen effective methods of preventing coronavirus disease (according to the August 2021 polled Ukrainians) were "washing your hands after leaving the street" (54%), "keeping distance from others" (42%), "being attentive to their well-being and the health of others" (39%), and "wearing a mask" (36%).

[86] Demand for vaccinations surged after new infections and deaths started to break records by late October 2021.

[89] Also on 25 October Ukrainian authorities reported a record daily high of 734 coronavirus-related deaths.

[90] Three days later the ministry stated that since the launch of the inoculation campaign 14,386,387 people had been vaccinated, of whom 14,386,385 received their first dose and 12,986,872 fully immunized (with two jabs).

[8] On 19 September 2022 the Ministry of Health announced the offer a third dose of the vaccine to everyone four months after their previous injection.

[93] The following information was reported as of 9:00 am on 27 July 2021:[94][non-primary source needed][95] Data from the occupied territories of Donetsk and Luhansk Oblasts, the Autonomous Republic of Crimea, and the city of Sevastopol is excluded from the daily updates by the Ukrainian Ministry of Healthcare.

The Cabinet of Ministers of Ukraine has set four different levels of epidemic danger:[113] These restrictions will not apply if all staff and all visitors, except those under 18, are fully vaccinated against COVID-19.