Jakarta has the highest percentage of population fully vaccinated with 103.46%, followed by Bali and Special Region of Yogyakarta with 85.45% and 83.02% respectively.

[11] On 11 January, the National Agency of Drug and Food Control (BPOM) published an emergency use authorization for CoronaVac from Sinovac Biotech for ages 18 to 59 with the second dose given 14 days after the first.

The Indonesian government confirmed vaccination would be compulsory for citizens and it would seek the private sector's help in inoculating the population.

[16] On 15 March, the government decided on four vaccines in use for the self-vaccination program for private employees: Sinopharm BIBP, Moderna, Sputnik V, and Novavax.

[18] On 19 March, the National Agency of Drug and Food Control (BPOM) authorized the resumption of distribution and use of the Oxford–AstraZeneca vaccine.

[21] On 8 April, Minister of Health Budi Gunadi Sadikin said there was no certainty regarding the arrival of 104 million doses of the Oxford–AstraZeneca vaccine committed under the COVAX initiative, due to export ban from India.

[24] On 21 April, the Ministry of Health said it would receive another 3,852,000 doses of the Oxford–AstraZeneca vaccine by early May, the second shipment to Indonesia under the COVAX initiative.

[26] On 30 April, the National Agency of Drug and Food Control (BPOM) issued an Emergency Use Authorization (EUA) for the Sinopharm BIBP vaccine.

[28] On 5 May, Jakarta expanded its vaccination program to include the general public at its dense and poor neighborhoods.

[46] On 27 June, the National Agency of Drug and Food Control (BPOM) published an emergency use authorization for CoronaVac for ages 12 to 17.

[49] On 2 July, the National Agency of Drug and Food Control of Indonesia (BPOM) published an emergency use authorization for the Moderna vaccine.

[citation needed] On 15 July, the National Agency of Drug and Food Control of Indonesia (BPOM) published an emergency use authorization for the Pfizer–BioNTech vaccine.

[55] On 16 July, the third inoculation for healthcare workers program using the Moderna vaccine was started at Dr. Cipto Mangunkusumo Hospital and the government announced that paid Gotong Royong vaccination program by Kimia Farma was cancelled after they received criticism from people who demanded it to be free.

[67] On 12 August, a nurse in Pluit, North Jakarta was found to be innocent after a video where she was allegedly inoculated an empty vaccine syringe went viral on the internet.

[citation needed] On 25 August, the National Agency of Drug and Food Control of Indonesia (BPOM) published an emergency use authorization for the Sputnik V vaccine.

This caused people to demand the Ministry of Communication and Information Technology to increase the safety of the PeduliLindungi app.

[84] On 7 September, the National Agency of Drug and Food Control of Indonesia (BPOM) published the emergency use authorization for Convidecia and the Janssen vaccine.

[106] On 7 October, the National Agency of Drug and Food Control of Indonesia (BPOM) published the emergency use authorization for Zifivax.

[123] The vaccine had also been approved by the National Agency of Drug and Food Control of Indonesia (BPOM) for ages 6 to 11.

[125] Also on this day, the National Agency of Drug and Food Control of Indonesia (BPOM) published the emergency use authorization for the Novavax vaccine, becoming the first country to do so.

[152] On 21 December, a man in Pinrang, South Sulawesi went viral on the internet after he claimed that he had been vaccinated 17 times on behalf of other people.

The government set a minimum of six months to elapse after the completion of primary vaccine before the booster dose could be administered.

[183] On 13 October, President Joko Widodo officially launched IndoVac, a COVID-19 vaccine developed by Indonesian pharmaceutical company Bio Farma and Baylor College of Medicine in Houston, Texas.

[184] On 29 November, National Agency of Drug and Food Control (BPOM) published an emergency use authorization on the use of Pfizer–BioNTech for children of 5 to 11 years old.

[185] On 11 December, National Agency of Drug and Food Control (BPOM) published an emergency use authorization on the use of Pfizer–BioNTech for infants of 6 months old up to 4 years old.

[190][191] During an outbreak in Kudus, Central Java, from 6,000 health professionals who were inoculated with CoronaVac, as of 12 June 2021, 308 of them were infected with COVID-19, 277 practice self-isolation, and 193 recovered.

The director of Dr. Loekmono Hadi Regional General Hospital, dr. Abdul Aziz Achyar, stated the vaccines were proven to be able to reduce sickness and death risk from COVID-19.

[192] On 18 June 2021, Reuters reported that more than 350 Indonesian doctors and medical workers had contracted SARS-CoV-2 despite being vaccinated with CoronaVac.

Griffith University epidemiologist, Dicky Budiman, said that it was unclear how effective CoronaVac was against the Delta variant.

[193] Based on observations study on 86,936 Jakarta residents aged 60 and above from March to April, CoronaVac is 85% effective against symptomatic illness and 92% against hospitalization.