The vaccination campaign was managed by the Ministry of Health and the special commissioner Domenico Arcuri until 1 March 2021,[2][3] when he was replaced by Army General Francesco Paolo Figliuolo.

[6] In the second phase of the campaign, elderly people and public service personnel should receive the vaccine.

The EU countries, as per previous agreements, received the vaccine provisions according to a centralized plan developed by the European Commission.

[12] On 6 January 2021, the European Medicines Agency (EMA) gave its authorization for the Moderna vaccine.

[12] According to a scientific study of COVID-19 virology, the Pfizer–BioNTech COVID-19 vaccine also protects against the two mutations of the virus that have spread in the United Kingdom and South Africa.

[15] Both strains share a common mutation called N501Y, a slight alteration at one point in the protein that covers the virus.

[15] On 10 January 2021, the Campania region in Italy had the highest percentage of administration compared to the doses possessed.

[19][20] On 16 January 2021, 800 doses of Moderna vaccine were lost due to freezer failure in Forlì.

[26] The European Union is in sharp confrontation with AstraZeneca on the timing and quantity of vaccine supplies.

[32] On 18 February 2021, the senator for life, Liliana Segre was vaccinated at Fatebenefratelli Hospital in Milan.

[34] [35] On 23 February 2021, AstraZeneca plans to supply less than half of the doses of vaccine preordered to the European Union.

[36] On 1 March 2021, The General of the Italian Army Francesco Paolo Figliuolo is the new special commissioner to replace Domenico Arcuri.

[4] On 9 March 2021, The President of the Italian Republic, Sergio Mattarella was vaccinated in the Spallanzani Hospital.

The Oxford University's Jenner Institute decision was made pending an analysis of the possible links between the drug and episodes of thrombosis among adults.

[53][54][55] On 2 May 2021, two anti-vaxxers were arrested and charged with terrorism offences for the firebombing at the Brescia vaccination centre.

[12][59][60] On 4 November 2021, The President of the Italian Republic, Sergio Mattarella, received the third dose of the vaccine in the Spallanzani Hospital.