[2] The CRON-diet involves calorie restriction in the hope that the practice will improve health and retard aging, while still attempting to provide the recommended daily amounts of various nutrients.
The subjects ate a diet low in fat and in calories but "nutrient-dense", derived from the food crops raised inside the Biosphere.
[7][8] The writer Christopher Turner in The Telegraph reported that Walford claimed that the diet "will retard your rate of ageing, extend lifespan (up to perhaps 150 to 160 years, depending on when you start and how thoroughly you hold to it), and markedly decrease susceptibility to most major diseases.
The review observed that one outcome had been the development of calorie restriction mimetic drugs which would be tested in clinical trials on humans.
[9] The journalist Pagan Kennedy wrote an opinion piece for The New York Times, mentioning Walford's book The 120 Year Diet and his hope of living for more than 100 years on the CRON diet, noting that instead he died of Lou Gehrig disease at age 79: her piece was titled "The Secret to a Longer Life?