The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.

[8] Gene polymorphism variants of CYP4A11 are associated with the development of hypertension and cerebral infarction (i.e. ischemic stroke) in humans (see 20-Hydroxyeicosatetraenoic acid).

Sesamin, the major lignan found in sesame, inhibits CYP4A11, which leads to decrease of plasma and urinary levels of 20-HETE.

[28] This result could be due to a decline in the production of EEQs and EPDs, which as indicated above, have blood pressure lowering actions.