CYP4F3

[5][6][7] CYP4F3 encodes two distinct enzymes, CYP4F3A and CYP4F3B, which originate from the alternative splicing of a single pre-mRNA precursor molecule; selection of either isoform is tissue-specific with CYP3F3A being expressed mostly in leukocytes and CYP4F3B mostly in the liver.

[8] The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, fatty acids and other lipids.

[9] This addition starts the process of inactivating and degrading all of these well-known mediators of inflammation[10] CYP3FA is the major enzyme accomplishing these omega oxidations in leukocytes.

[8] The hydroxylation-induced inactivation of the mediators of inflammation, perhaps particularly of leukotriene B4, may underlie the proposed roles of these cytochromes in dampening inflammatory responses as well as the reported associations of certain CYP4F3 single nucleotide variants (SNPs) with human Crohn's disease (SNPs are designated rs1290617[11] and rs1290620[12] and celiac disease (rs1290622 and rs1290625).

[8][13][14][15][16] There is also a study that have found an association within Guangzhou population between the single nucleotide variation rs3794987 and susceptibility to the SARS-CoV-1 virus, discovered in 2003.