C Spire provides service in Mississippi, the Memphis Metropolitan Area, and parts of Alabama including Mobile and Baldwin County.

[6] In 2013, C Spire announced it was purchasing Mobile, Alabama based Callis Communications, a provider of unified cloud services for businesses.

In January 2021, the company announced it would be investing US$1 billion over three years to deploy broadband internet to serve more than 200,000 homes and businesses in Mississippi and Alabama and support the expansion of 5G access.

With this acquisition, the company is providing fiber-based broadband internet access and related services to several cities and towns in Mobile and Baldwin counties on Alabama's Gulf Coast.

[14] In October 2021, C Spire announced it will acquire Alabama-based telecommunications provider Troy Cablevision in a deal subject to regulatory approval.

Troy Cablevision was founded in 1985 and offers cable, internet and other services to businesses and residents in Pike, Coffee, Crenshaw and Dale counties.

Former football quarterback Archie Manning made the company's inaugural call from Gulfport, Mississippi to then U.S. Representative Trent Lott in Washington, D.C.[16] In 2011, C Spire became the fourth wireless carrier in the U.S., behind AT&T, Sprint and Verizon, to be able to sell the iPhone.