Cabeza de Vaca is a 1991 Mexican film directed by Nicolás Echevarría and starring Juan Diego about the adventures of Álvar Núñez Cabeza de Vaca (c. 1490 – c. 1557), an early Spanish explorer, as he traversed what later became the American South.

Cabeza de Vaca was one of four survivors of the Narváez expedition and shipwreck.

He became known as a shaman among the Native American tribes he encountered, which helped him survive.

The screenplay by Guillermo Sheridan and Nicolás Echevarría is based on Cabeza de Vaca's journal Naufragios y comentarios ("Shipwrecks and Commentaries").

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