Cabramatta Creek flows through established residential suburbs, including Miller, Cartwright, Sadlier, Ashcroft, Liverpool, Mount Pritchard and Warwick Farm.

[2] Cabramatta Creek rises in the rural/residential suburb of Denham Court, east south-east of Leppington, within the Liverpool local government area.

Below Hoxton Park Road, Cabramatta Creek starts to flow in an easterly direction the Fairfield local government area, towards its confluence with the Georges River, to the east of Warwick Farm.

The Elouera Nature Reserve, which is an important pocket of native bushland, also forms part of this corridor.

Major transport routes that cross the catchment includes Hoxton Park Road, Elizabeth Drive, Orange Grove Road (the Cumberland Highway), the Hume Highway and the Main Southern railway line.