She was married to Eduard Seler the philologist, historian and specialist in Mesoamerican indigenous cultures, and she supplied photographs for most of his publications, and her inherited fortune supported both of their research.
When her husband was immobilized by illness during their travels, she and a Native guide ventured alone into the jungle on horseback, where she looked for ruins and made drawings of architecture and iconography.
Nonetheless, her primary interest was in ethnology, the study of the forms of life of contemporary indigenous peoples.
Ein Blatt aus der Kulturgeschichte Altmexikos" (Women's lives in the realm of the Aztecs.
An aspect of ancient Mexican cultural history) in which she describes the lives of women in Aztec period Mexico.