The company was founded in San Mateo, California, but is now headquartered in Louisville, Kentucky, where its production facility is also located.

The site also allows users to have a virtual CafePress "shop", including an online storefront and website hosting, order management, fulfillment, payment processing, and customer service.

[6] On April 30, 2012, CafePress announced that it would move its corporate headquarters from San Mateo, California, to its production facilities in Louisville, Kentucky, at a cost of $16.5 million.

[19] As of October 2024, The Federal Trade Commission (FTC) has initiated payments totaling over $370,000 to consumers adversely affected by the data security lapses of CafePress.

CafePress, Inc. also partners with other businesses to provide licensed content on their site, and power online custom shops for large companies, such as ABC, Urban Outfitters and Peanuts Worldwide.