Cagayan de Oro's 2nd congressional district is one of the two congressional districts of the Philippines in Cagayan de Oro.

It has been represented in the House of Representatives since 2007.

[3] It was created by the 2007 reapportionment that divided the city into two congressional districts and which took effect in the same year.

[4] The district is composed of the barangays located east of the Cagayan River and includes the city's downtown commercial core and port area.

It is currently represented in the 19th Congress by Rufus Rodriguez of the Centrist Democratic Party of the Philippines (CDP).