[1] This area today comprises the modern municipalities of Caguas, Aguas Buenas, Gurabo, and portions of San Lorenzo, Juncos and Las Piedras in east-central Puerto Rico.

[2] Guaybanex Caguax was an early convert to the Catholic faith; he adopted the Spanish name Francisco at the time of his baptism.

This sort of peace treaty allowed Ponce de León to settle the island and to receive cooperation from Agüeybaná I's cacique allies in order to grow the yuca that was needed to feed the Spanish settlers.

Archaeologist Carlos A. Pérez Merced, excavating in the area, found ceramic and pottery from three different indigenous periods: Igneri, pre-Taino and Taino.

Early in 1512, Cerón redistributed Ponce de León's caciques among his friends and banished Caguax, along with his relatives and entourage, to Hacienda del Toa in the northern coastal plain, west of Caparra, the first Spanish settlement on the island.

His mother, siblings, wives and children have been identified by records that were sent to la Real Hacienda to account for the distribution of clothes and other goods, called the "cacona", which were given to the indigenous people in captivity once a year between 1513 and 1519.

With no living heirs in the line of succession, María Bagaaname, Caguax's eldest daughter,[11][12] was ceded the right to bear the successor.

[13] As for the nitainos who had been forced to move with Caguax to oversee the work in Hacienda del Toa, records show that Aguayayex, Guayex, Caguas, Juanico Comerio, Juan Acayaguana, Diego Barrionuevo, Esteban directed agricultural tasks and that Pedro was in charge of the mines.