It operates scheduled domestic and international flights within the Caribbean region.

Caicos Express Airways was founded in 2007 by Captain Registre, initially operating charter flights with a Piper Aztec PA23.

The company expanded when Captain Arthur joined, adding a Cessna 402 to the fleet and broadening services to include charter business and non-critical medical transport.

In December 2011, the airline began scheduled flights within the Turks and Caicos Islands.

Caicos Express has since expanded its fleet and destinations, adding routes to the Dominican Republic and, in 2023, to Jamaica.