Cairo is a village in Randolph County, Missouri, United States.

[6] The Mitchell Petroglyph Archeological Site was listed on the National Register of Historic Places in 1969.

[7] According to the United States Census Bureau, the village has a total area of 0.31 square miles (0.80 km2), all land.

18.9% of all households were made up of individuals, and 7.6% had someone living alone who was 65 years of age or older.

28.2% of all households were made up of individuals, and 14.5% had someone living alone who was 65 years of age or older.

About 11.4% of families and 10.2% of the population were below the poverty line, including 16.3% of those under the age of eighteen and 26.3% of those 65 or over.