The Mustangs are an NCAA Division I college baseball program, and along with the other Cal Poly athletic teams with the exception of swimming, wrestling, indoor track and football, the baseball team competes in the Big West Conference.

The Cal Poly Mustangs play all home games on campus at Robin Baggett Stadium.

Under the direction of Head Coach Larry Lee, the Mustangs have played in three NCAA tournaments—2009, 2013, and 2014—including hosting their first regional in 2014.

Conference tournament champion Taken from the 2019 Cal Poly baseball media guide.

Cal Poly was featured as a playable team in EA's MVP '06: NCAA Baseball game for PlayStation 2 and Xbox.