The team's home venue is Cicerone Field at Anteater Ballpark located on campus in Irvine, California.

Since moving to Division I play they have appeared in the NCAA tournament ten times and the College World Series twice.

[3] Prior to the 1978 season, the program joined the newly formed Division I Southern California Baseball Association (SCBA).

[6][7][8] When Steve Hertz returned to Gonzaga following the 1980 season, Mike Gerakos became the program's head coach.

UC Irvine then became members of the Pacific Coast Athletic Association, which was renamed the Big West Conference prior to the 1987 season.

[12] Following the 2000 college baseball season, the school hired USC assistant John Savage as the program's new head coach.

Its first game, also the opening of the newly built Anteater Ballpark, was an 8-5 loss to San Diego on January 25, 2002.

In the South Bend Regional, the team lost consecutive games to Arizona and Notre Dame and was eliminated.

[15] UC Irvine hired Cal State Fullerton assistant coach Dave Serrano to replace him.

[3] Following the 2007 season, Dave Serrano returned to Cal State Fullerton to become the team's head coach.

[3] In the team's 2009 season, the Anteaters won the Big West Championship with a 22-2 conference record and qualified for the NCAA tournament as the #6 National Seed.

Cicerone Field at Anteater Ballpark has been the program's home venue since it opened in 2002, also the year in which UC Irvine sponsored varsity baseball for the first season since 1992.