Calamine is an unincorporated community in the town of Willow Springs in Lafayette County, Wisconsin, United States.

The community is home to 100 year old St. Michael Church, within the Roman Catholic Diocese of Madison.

Formerly Calamine was a bustling community with prosperous mines and farms with an active rail road.

Later the Cornland fertilizer plant was built and supplied farmers for miles around with granular and liquid fertilizer, making the nearby Pecatonica River bottoms top producers in non flood yearsNorth of Calamine there was a popular swimming hole known as the “Mill” on the Pecatonica River named after a prehistoric grist Mill which was burned to the ground during the Blackhawk war.

Fourth Cavalry troopers from Fort Defiance were unable to extinguish it and through the procedure somehow discovered this great swimming hole.