Calcis is an unincorporated community in Shelby County, Alabama, United States, located along Alabama State Route 25, 3 miles (4.8 km) north-northwest of Vincent.

The community's name is derived from the word calcium, in reference to the limestone that was mined in the local quarries.

[2] Calcis is located on the former Central of Georgia Railway and was once home to a passenger depot.

[4] The Tennessee Coal, Iron and Railroad Company operated a limestone quarry in Calcis.

This Shelby County, Alabama state location article is a stub.