Caleb Afendopolo (born at Adrianople December 1, 1464;[1] lived some time at Belgrade, and died March 1523[2] at Constantinople) was a Jewish polyhistor.
He was the brother of Samuel ha-Ramati, ḥakam of the Karaite congregations in Constantinople and of Judah Bali, brother-in-law and disciple of Elijah Bashyatzi.
A pupil of Mordecai Comtino at Adrianople, Afendopolo attained great proficiency in science, and, while lacking depth and originality of thought, distinguished himself by prolific literary production, based on his large library, that included rare manuscripts, partly bought, partly copied by himself.
He continued Adderet Eliyahu (Elijah's Mantle), a work on Karaite law left unfinished in his charge by his teacher, Bashyatzi, in 1490.
Afendopolo had intended to translate the Elements of Euclid, and to write commentaries on Jabir ibn Aflaḥ's Kitab al-Ḥiyyah (Compendium on Astronomy) and on Ptolemy's Almagest.